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[Multiple sclerosis and botulinum toxin].

D Lamotte1, P Thoumie

  • 1Service de rééducation neuro-orthopédique, hôpital Rothschild, 33, boulevard de Picpus, 75012 Paris, France. delphine.lamotte@ap-hop-paris.fr

Annales De Readaptation Et De Medecine Physique : Revue Scientifique De La Societe Francaise De Reeducation Fonctionnelle De Readaptation Et De Medecine Physique
|August 21, 2003
PubMed
Summary

Botulinum toxin effectively treats spasticity in multiple sclerosis patients. While generally safe, further research is needed to confirm optimal injection sites and manage potential side effects like muscle weakness.

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Area of Science:

  • Neurology
  • Pharmacology

Context:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Spasticity is a common and debilitating symptom in MS patients.
  • Botulinum toxin is a neurotoxin with therapeutic applications.

Purpose:

  • To review existing literature on the efficacy of botulinum toxin for multiple sclerosis symptoms.
  • To identify the primary indications and effectiveness of botulinum toxin treatments in MS.
  • To assess the safety and side effect profile of botulinum toxin in MS patients.

Summary:

  • A literature review (1982-2002) identified 37 articles, retaining 6 controlled studies on botulinum toxin in MS.
  • The primary application identified was the management of spasticity, with positive outcomes reported for muscle tone, spasms, and pain.

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  • Limited evidence also suggested potential benefits for acquired nystagmus and vocal fold paralysis, though further investigation is warranted.

    • Impact:

    • Botulinum toxin is a viable treatment option for MS-related spasticity.
    • The review highlights the need for more rigorous, placebo-controlled trials to establish definitive efficacy and optimal usage.
    • Understanding and managing potential side effects, such as muscle weakness, is crucial for patient care.