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[Digestive tract and botulinum toxin].

M Gaudric1, S Chaussade

  • 1Service d'hépatogastroentérologie, hôpital Cochin, 27, rue du faubourg-Saint-Jacques, 75014 Paris, France. marianne.gaudric@cch.ap-hop-paris.fr

Annales De Readaptation Et De Medecine Physique : Revue Scientifique De La Societe Francaise De Reeducation Fonctionnelle De Readaptation Et De Medecine Physique
|August 21, 2003
PubMed
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Botulinum toxin injections show efficacy for esophageal achalasia and anal fissure, offering a palliative role for achalasia and potential cure for anal fissure. Further controlled trials are needed for other gastrointestinal motor disorders.

Area of Science:

  • Gastroenterology
  • Pharmacology

Context:

  • Gastrointestinal motor disorders are a group of conditions affecting gut motility.
  • Botulinum toxin injections are increasingly utilized for managing these disorders.

Purpose:

  • To review the literature and assess the efficacy of botulinum toxin injections in treating gastrointestinal motor disorders.
  • To specifically evaluate controlled clinical trials on botulinum toxin efficacy.

Summary:

  • A literature search identified seventy-three relevant articles.
  • Controlled trials were limited to achalasia and anal fissure.
  • Other gastrointestinal motor disorders lacked controlled studies, relying on open-label assessments.

Impact:

  • Botulinum toxin is effective for esophageal achalasia (palliative) and anal fissure (curative).

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  • The primary limitation is the short duration of action.
  • More controlled trials are necessary to establish efficacy for other spastic gastrointestinal motor disorders due to unknown pathophysiology.