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[Montelukast-free interval before inhalational bronchial allergen provocation].
F-W Riffelmann1, G Droste, H Lauter
1Fachkrankenhaus Kloster Grafschaft, Zentrum für Pneumologie, Beatmung und Schlafmedizin, Allergologie, Schmallenberg. f.riffelmann@fkkg.de
Pneumologie (Stuttgart, Germany)
|August 21, 2003
Summary
To avoid impacting allergy test results, discontinue montelukast (a leukotriene receptor antagonist) at least three days before bronchial allergen provocation. This allows the body to clear the medication.
Area of Science:
- Allergy and immunology research
- Pharmacology of respiratory diseases
Background:
- Leukotrienes are key mediators in asthma, causing bronchoconstriction and inflammation.
- Previous research demonstrated montelukast's efficacy in suppressing allergen-induced asthma responses.
- This study investigated the optimal washout period for montelukast before allergy testing.
Purpose of the Study:
- To determine the necessary duration for discontinuing montelukast before inhalational bronchial allergen provocation.
- To assess the impact of varying montelukast-free intervals on allergen provocation test sensitivity.
Main Methods:
- Asthma patients (n=16) received montelukast (10 mg daily) for 21 days.
- Allergen provocation tests were repeated after 1-day and 3-day montelukast-free periods.
- Results were compared to baseline values without montelukast.
Main Results:
- Allergen provocation dose decreased by 39% after a 1-day washout.
- A 67% reduction in provocation dose was observed after a 3-day washout.
- Significant recovery towards baseline was noted only after three days (p=0.017).
Conclusions:
- Montelukast should be discontinued at least three days prior to inhalational allergen provocation.
- A three-day washout period is recommended to minimize interference with allergy testing.
- This ensures more accurate assessment of bronchial hyperresponsiveness to allergens.