Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CNS gene expression pattern associated with spontaneous experimental autoimmune encephalomyelitis.

Agata Matejuk1, Corwyn Hopke, Jami Dwyer

  • 1Department of Neurology, Oregon Health and Science University, Portland, Oregon.

Journal of Neuroscience Research
|August 21, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving arrhythmic risk prediction using cardiac magnetic resonance within deep learning in ischemic heart disease.

NPJ cardiovascular health·2026
Same author

Prevalence and Clinical Importance of Right Ventricular Involvement in Mild Dilated Cardiomyopathy.

Journal of the American Heart Association·2026
Same author

Altered Lipid Metabolism in CNS Demyelination and Remyelination Are Key Elements Driving Progressive MS.

International journal of molecular sciences·2025
Same author

Fibrosis Entropy Is Associated With Life-Threatening Arrhythmia in Nonischemic Cardiomyopathy.

Journal of the American Heart Association·2025
Same author

Visually assessed ischemia on cardiac magnetic resonance, but not quantitative perfusion metrics, predicts symptomatic improvement in coronary artery bypass.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance·2025
Same author

In Silico Trials for Sex-Specific patient Inclusion Criteria in Cardiac Resynchronization Therapy: Advancing Precision in Heart Failure Treatment.

ArXiv·2025

Transgenic mice spontaneously develop experimental autoimmune encephalomyelitis (EAE), offering a new model for studying this autoimmune disease. Gene expression analysis reveals key pathways involved in EAE development without immunization.

Area of Science:

  • Neuroimmunology
  • Autoimmune Diseases
  • Genomics

Background:

  • Experimental autoimmune encephalomyelitis (EAE) is a model for multiple sclerosis.
  • Understanding spontaneous EAE offers insights into disease pathogenesis without external triggers.

Purpose of the Study:

  • To characterize the transcriptional changes during spontaneous EAE development in T/R- mice.
  • To identify key genes and pathways involved in the natural onset of EAE.

Main Methods:

  • Utilized transgenic mice (T/R-) with a T-cell receptor specific for myelin basic protein (MBP).
  • Performed microarray analysis on spinal cord tissue from symptomatic and non-symptomatic mice.
  • Analyzed gene expression related to antigen presentation, inflammation, and CNS-specific processes.

Related Experiment Videos

Main Results:

  • Spontaneous EAE development was observed in T/R- mice.
  • Upregulated transcripts were identified in antigen presentation, signal transduction, metabolism, and cell cycle pathways.
  • Genes associated with inflammation, including cytokines and chemokines, were highly expressed.
  • CNS-specific genes and monocyte/macrophage markers were upregulated in affected mice.

Conclusions:

  • This study provides the first description of spontaneous EAE pathogenesis without immunization.
  • Identified critical molecules and pathways naturally contributing to EAE, paralysis, and demyelination.
  • Findings may offer novel therapeutic strategies for multiple sclerosis and related human diseases.