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Peripheral neuropathy in scleroderma.

Ann N Poncelet1, M Kari Connolly

  • 1Department of Neurology, Box 0114, University of California, San Francisco, San Francisco, California 94143, USA. ponce@itsa.ucsf.edu

Muscle & Nerve
|August 21, 2003
PubMed
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Peripheral neuropathy is common in scleroderma patients, affecting nerve function in both large and small fibers. Further research is needed to understand the causes of this nerve damage in scleroderma.

Area of Science:

  • Neurology
  • Rheumatology

Background:

  • Scleroderma patients frequently report neuropathic symptoms like numbness and tingling.
  • Peripheral nerve involvement is a recognized but often underestimated complication of scleroderma.

Purpose of the Study:

  • To assess peripheral nerve function in patients with scleroderma.
  • To determine the frequency and characteristics of neuropathy in scleroderma.

Main Methods:

  • Fourteen scleroderma patients underwent neurologic examination.
  • Nerve conduction studies (NCS) and quantitative sensory testing (QST) were performed.
  • Sensory and motor nerve function, including detection thresholds, were evaluated.

Main Results:

  • Neurologic exams revealed sensory loss, atrophy, weakness, and reduced reflexes in some patients.

Related Experiment Videos

  • NCS indicated reduced sensory nerve potentials and carpal tunnel syndrome in a few cases.
  • QST showed increased cold or vibration detection thresholds in over half of the patients (8/14).

    • Conclusions:

    • Peripheral neuropathy is more frequent in scleroderma than previously thought.
    • The neuropathy involves both large and small nerve fibers in a non-length-dependent manner.
    • Further prospective and pathological studies are required to elucidate the neuropathy's characteristics and etiology.