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Total synthesis of (+/-)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi
Martin G Banwell1, Alison J Edwards, Katrina A Jolliffe
1Research School of Chemistry, Institute of Advanced Studies, Australian National University, Canberra, ACT 0200, Australia. mgb@rsc.anu.edu.au
Organic & Biomolecular Chemistry
|August 22, 2003
Abstract:
The title alkaloid 1 and its B-nor-congener 3, both of which display potent and unusual anti-mitotic properties, have been synthesized in racemic form and characterised by single-crystal X-ray analysis.