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Bone turnover in overt and subclinical hyperthyroidism due to autonomous thyroid adenoma
E De Menis1, G Da Rin, I Roiter
1Divisione Medica, Ospedale Regionale di Treviso, Italy.
Hormone Research
|January 1, 1992
Summary
Autonomous thyroid adenoma significantly increases bone turnover in premenopausal women with overt hyperthyroidism. Bone formation and resorption markers are elevated, unlike in subclinical cases.
Area of Science:
- Endocrinology
- Bone Metabolism
- Thyroid Disorders
Background:
- Autonomous thyroid adenoma can cause hyperthyroidism.
- Thyroid hormones significantly influence bone metabolism.
- Premenopausal women are susceptible to bone density changes.
Purpose of the Study:
- To investigate bone turnover parameters in premenopausal women with autonomous thyroid adenoma.
- To differentiate bone metabolism changes between overt and subclinical hyperthyroidism.
- To assess the impact of elevated free thyroid hormones on bone health.
Main Methods:
- Studied 20 premenopausal women with autonomous thyroid adenoma (7 overt hyperthyroidism, 13 subclinical hyperthyroidism).
- Included 11 healthy premenopausal women as controls.
- Measured serum calcium, urinary hydroxyproline, serum osteocalcin, and alkaline phosphatase.
Main Results:
- Overt hyperthyroidism group showed significantly increased bone resorption and formation markers compared to controls and subclinical group.
- Subclinical hyperthyroidism group had no significant alterations in bone metabolism compared to controls.
- Elevated free thyroid hormones correlated with increased bone turnover.
Conclusions:
- Autonomous thyroid adenoma with overt hyperthyroidism significantly elevates bone turnover in premenopausal women.
- Subclinical hyperthyroidism associated with autonomous thyroid adenoma does not significantly alter bone metabolism.
- Monitoring bone health is crucial in premenopausal women with overt hyperthyroidism due to thyroid adenoma.