Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

What can be expected from optimal blood pressure control?

Jan A Staessen1, Ji-Guang Wang, Lutgarde Thijs

  • 1Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium. jan.staessen@med.kuleuven.ac.be

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|August 22, 2003
PubMed
Summary

Achieving tight blood pressure control is crucial for reducing cardiovascular risks. This meta-analysis shows blood pressure levels, not drug classes, primarily determine outcomes in hypertensive patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relation of Insulin Resistance to Longitudinal Changes in Left Ventricular Structure and Function in a General Population.

Journal of the American Heart Association·2018
Same author

Associations of Urinary Caffeine and Caffeine Metabolites With Arterial Stiffness in a Large Population-Based Study.

Mayo Clinic proceedings·2018
Same author

Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction.

PloS one·2018
Same author

Association of pulse wave velocity with single nucleotide polymorphisms related to parathyroid hormone.

Blood pressure·2018
Same author

Management of a Pregnant Woman With Fibromuscular Dysplasia.

Hypertension (Dallas, Tex. : 1979)·2018
Same author

Letter to editor: Blood pressure, hypertension and lead exposure.

Environmental health : a global access science source·2018

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Trials

Background:

  • Hypertension management involves various drug classes with debated impacts on cardiovascular outcomes.
  • Recent trials compare newer (ACE inhibitors, calcium channel blockers) versus older (diuretics, beta-blockers) antihypertensive agents.

Purpose of the Study:

  • To analyze how different antihypertensive drug classes and blood pressure control levels affect cardiovascular morbidity and mortality in high-risk patients.
  • To evaluate the efficacy of nitrendipine-based therapy in specific patient populations.

Main Methods:

  • Meta-regression analysis of 30 clinical trials encompassing 149,407 patients.
  • Analysis based on reported summary statistics from published literature.
  • Specific study on older patients with isolated systolic hypertension and diabetic patients.

Related Experiment Videos

Main Results:

  • Blood pressure gradients explained most outcome variations in hypertensive or high-risk individuals.
  • Nitrendipine-based treatment reduced stroke and cardiovascular complications in older adults with isolated systolic hypertension.
  • Nitrendipine therapy decreased dementia incidence, proteinuria, total mortality, and improved cardiovascular prognosis in diabetic patients.

Conclusions:

  • Tight blood pressure control is highly desirable for managing hypertension and its complications.
  • Blood pressure reduction, rather than specific drug classes, is the primary driver of improved cardiovascular outcomes.
  • Nitrendipine demonstrates significant benefits across various high-risk patient groups.