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Related Experiment Videos

Day 3 versus day 5 embryo transfer: a prospective randomized study.

M Bungum1, L Bungum, P Humaidan

  • 1Fertility Clinic, Skive Hospital, Skive, Denmark. mona.bungum@sygehusviborg.dk

Reproductive Biomedicine Online
|August 22, 2003
PubMed
Summary

Blastocyst (day 5) versus day 3 embryo transfer showed similar implantation and pregnancy rates in a randomized study. This suggests day 5 transfer offers no significant advantage when equal numbers of viable embryos are transferred.

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Area of Science:

  • Reproductive Endocrinology
  • In Vitro Fertilization (IVF)

Background:

  • Blastocyst (day 5) embryo transfer is often linked to high implantation rates.
  • Limited prospective randomized studies exist comparing day 3 and day 5 embryo transfers.
  • Previous studies often transferred more embryos on day 3 than blastocysts on day 5, confounding comparisons.

Purpose of the Study:

  • To compare the implantation and pregnancy potential of embryos transferred on day 3 versus day 5.
  • To evaluate if blastocyst transfer offers an advantage over day 3 transfer under specific conditions.

Main Methods:

  • A prospective randomized study involving 118 patients undergoing standard IVF/intracytoplasmic sperm injection.
  • Patients with at least three 8-cell embryos (<20% fragmentation) on day 3 were randomized for day 3 or day 5 transfer.

Related Experiment Videos

  • A maximum of two embryos were transferred in each group, ensuring equal numbers were replaced.

    • Main Results:

    • No statistically significant differences were observed between day 3 and day 5 transfer groups in human chorionic gonadotrophin (70% vs. 67%), clinical pregnancy (61% vs. 51%), implantation (44% vs. 37%), twinning (42% vs. 41%), or early pregnancy loss rates (15% vs. 29%).
    • Similar implantation rates were achieved when equal numbers of embryos were transferred on day 3 or day 5.
    • The study found no advantage for blastocyst transfer over day 3 transfer in selected patients.

    Conclusions:

    • Embryo transfer on day 3 or day 5 yields similar implantation rates when an equal number of viable embryos are transferred.
    • Blastocyst stage transfer does not appear to offer a significant advantage over day 3 transfer for patients with multiple good-quality embryos available on day 3.