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Updated: Sep 20, 2026

Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores: is
R K Burt1, Yu Oyama, A Traynor
1Department of Medicine, Division of Immunotherapy, Northwestern University Medical Center, 320 East Superior, Searle 3-489, Chicago, IL 60611, USA.
Abstract:
Systemic sclerosis (SSc) is presumed to be an immune-mediated vasculopathy of unknown etiology. SSc is unresponsive to most immune-modulating therapies except for intravenous cyclophosphamide, which is reported to demonstrate some benefit. We, therefore, dose-escalated cyclophosphamide to 200 mg/kg and added rabbit ATG 7.5 mg/kg along with infusion of unselected hematopoietic stem cells to minimize the cytopenic interval. Engraftment occurred rapidly (day 8) with minimal unexpected toxicity, no infections, and unexpectedly rapid improvement in the modified Rodnan Skin Score.
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