Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Will it be possible to produce peripheral nerves?

Mikael Wiberg1, Giorgio Terenghi

  • 1Department of Surgical and Peri-Operative Science Section of Hand and Plastic Surgery, University Hospital, Umeå University, Umeå, Sweden.

Surgical Technology International
|August 22, 2003
PubMed
Summary

Peripheral nerve injuries often result in poor functional recovery due to neuron death and limited regeneration. Alternative methods are needed to bridge nerve gaps, as current autografts have significant drawbacks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quercetin-derived carbon dots promote proliferation and migration of Schwann cells and enhance neurite outgrowth.

Colloids and surfaces. B, Biointerfaces·2025
Same author

The influence of xeno-free culture conditions on the angiogenic and adipogenic differentiation properties of adipose tissue-derived stem cells.

Regenerative therapy·2025
Same author

The impact of a soft robotic glove on activity performance and body function for brachial plexus birth injury patients-A longitudinal case series.

Journal of hand therapy : official journal of the American Society of Hand Therapists·2024
Same author

Demographics and deprivation in obstetric brachial plexus palsy: a retrospective cohort study.

The Journal of hand surgery, European volume·2023
Same author

Platelet lysate for expansion or osteogenic differentiation of bone marrow mesenchymal stem cells for 3D tissue constructs.

Regenerative therapy·2023
Same author

Bioengineered nerve conduits and wraps for peripheral nerve repair of the upper limb.

The Cochrane database of systematic reviews·2022

Area of Science:

  • Neurosurgery
  • Regenerative Medicine
  • Biomaterials

Background:

  • Peripheral nerve injuries are common, particularly in the upper extremity, leading to significant disability.
  • Current surgical repair outcomes, especially for sensory recovery, are often poor.
  • Nerve gap length dictates repair strategy, with long gaps requiring grafts.

Purpose of the Study:

  • To highlight the limitations of current peripheral nerve repair techniques.
  • To emphasize the need for alternative methods for bridging nerve gaps.
  • To discuss the shortcomings of autologous nerve grafts.

Main Methods:

  • Review of current literature on peripheral nerve repair.
  • Analysis of outcomes following different nerve repair strategies.

Related Experiment Videos

  • Evaluation of autologous nerve graft (ANG) techniques and their associated morbidities.

    • Main Results:

    • Optimal surgical repair yields suboptimal functional outcomes, particularly sensory recovery.
    • Primary sensory neuron death, lack of fiber regeneration, and target-organ denervation contribute to poor results.
    • Autologous nerve grafts, while standard, cause donor site morbidity and have limitations.

    Conclusions:

    • Existing methods for peripheral nerve reconstruction, including autografts, are insufficient.
    • There is a critical need for innovative alternative strategies to improve nerve gap bridging.
    • Developing new approaches is essential for enhancing functional recovery after nerve injury.