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Related Experiment Videos

Vernal keratoconjunctivitis in Thailand.

Panida Kosrirukvongs1, Pakit Vichyanond, Warapat Wongsawad

  • 1Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Asian Pacific Journal of Allergy and Immunology
|August 23, 2003
PubMed
Summary

Vernal keratoconjunctivitis (VKC) treatment outcomes varied by VKC type and medication. Topical cyclosporine showed promise for severe VKC, especially limbal types, offering an alternative to steroids.

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Area of Science:

  • Ophthalmology
  • Allergy and Immunology

Background:

  • Vernal keratoconjunctivitis (VKC) is a chronic allergic eye condition.
  • VKC presents with various clinical features and requires tailored treatment strategies.

Purpose of the Study:

  • To investigate the clinical features and treatment outcomes of VKC in Thai patients.
  • To compare the efficacy of different topical medications for VKC management.

Main Methods:

  • Prospective, cross-sectional, and randomized cross-over study design.
  • Inclusion of history-taking, eye examinations, and weekly symptom/sign evaluation.
  • Treatment regimens included topical antihistamines, lodoxamide, corticosteroids, and cyclosporine.

Main Results:

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  • Palpebral VKC symptoms were more severe and triggered by house dust.
  • Limbal VKC was more frequently associated with allergic rhinitis.
  • Topical cyclosporine demonstrated a 100% success rate in mixed VKC types, outperforming lodoxamide and comparable to corticosteroids in some cases, despite a burning sensation in palpebral VKC.

    • Conclusions:

    • Grading VKC severity is crucial for effective treatment.
    • Topical cyclosporine 0.5% is a viable alternative for VKC symptom relief, potentially avoiding steroid-induced glaucoma.
    • Levocabastine hydrochloride and lodoxamide are effective for mild to moderate VKC, while corticosteroids are for severe cases short-term.