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The pterocellins, novel bioactive alkaloids from the marine bryozoan Pterocella vesiculosa
Biao Yao1, Michèle R Prinsep, Brian K Nicholson
1Department of Chemistry, University of Waikato, Private Bag 3105, Hamilton, New Zealand.
Abstract:
Two new alkaloids, pterocellins A and B, have been isolated from the New Zealand marine bryozoan Pterocella vesiculosa. Structural elucidation was achieved through NMR and mass spectral analysis in conjunction with a single-crystal X-ray diffraction study of pterocellin A. The pterocellins possess a novel heterocyclic skeleton and exhibit potent antitumor activity and antimicrobial activity in vitro but only modest activity in the in vivo hollow fiber assay at the National Cancer Institute.
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