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Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus
Tsunashi Kamo1, Masashi Asanoma, Hisao Shibata
1Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, 8304 Minami-minowa, Kami-ina, Nagano 399-4598, Japan.
Journal of Natural Products
|August 23, 2003
Abstract:
Six lanostane-type triterpene acids were isolated from the fruiting bodies of Piptoporus betulinus. They were identified as polyporenic acids A (1) and C (2), three derivatives of polyporenic acid A (3-5), and a novel compound, (+)-12 alpha,28-dihydroxy-3 alpha-(3'-hydroxy-3'-methylglutaryloxy)-24-methyllanosta-8,24(31)-dien-26-oic acid (6). All these compounds suppressed the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced edema on mouse ears by 49-86% with a 400 nmol/ear application.