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The T cell surface--how well do we know it?

Edward J Evans1, Lawrence Hene, Lisa M Sparks

  • 1Nuffield Department of Clinical Medicine, The University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom.

Immunity
|August 23, 2003
PubMed
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Researchers analyzed the resting cytotoxic T cell surface, identifying 111 expressed leukocyte surface antigens. Unexpectedly, few T cell-specific transcripts encode proteins with typical surface antigen architecture, largely defining the CD8+ T cell surface composition.

Area of Science:

  • Immunology
  • Cell Biology
  • Genomics

Background:

  • The complexity of the T cell surface proteome remains largely undefined, hindering a comprehensive understanding of T cell biology and function.
  • Existing knowledge of leukocyte surface antigens is extensive, but their specific expression and functional relevance on resting cytotoxic T cells are unclear.

Purpose of the Study:

  • To comprehensively define the cell type-specific composition of the resting cytotoxic T cell surface.
  • To investigate the functional and structural characteristics of T cell-specific transcripts expressed on the T cell surface.

Main Methods:

  • Global gene expression analysis of resting cytotoxic T cells.
  • Bioinformatic analysis of known leukocyte surface antigen genes and novel T cell-specific transcripts.

Related Experiment Videos

  • Assessment of protein modular architecture and membrane topology for identified transcripts.

    • Main Results:

    • 111 out of 374 well-characterized leukocyte surface antigen genes are expressed on resting cytotoxic T cells.
    • 97 T cell-specific transcripts with unknown functions were identified.
    • None of the identified T cell-specific transcripts possess the typical modular architecture of known surface antigens; only two exhibit exclusive cell surface molecule topologies.

    Conclusions:

    • The cell type-specific composition of the resting CD8+ T cell surface is now largely defined.
    • This study provides a framework for understanding the complexity of the mammalian cell surface and T cell surface-dependent processes like T cell receptor triggering.