Related Experiment Video
Updated: Jan 3, 2026
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Micelles from polyethylene glycol/phosphatidylethanolamine conjugates for tumor drug delivery
Anatoly N Lukyanov1, Zhonggao Gao, Vladimir P Torchilin
1Department of Pharmaceutical Sciences, Bouve College of Health Sciences, 312 Mugar Bldg., Northeastern University, Boston, MA 02115, USA. a.lukyanov@nea.edu
Abstract:
Micelles prepared from polyethylene glycols of various lengths conjugated with phosphatidylethanolamine (PEG-PE) were loaded with various poorly soluble anticancer agents. PEG-PE micelles selectively accumulated in Lewis lung carcinoma (LLC) tumors implanted in mice. Modification of the micelles with tumor specific antibodies further enhanced the efficiency of tumor accumulation.
