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Serum highly sensitive C-reactive protein in preterm premature rupture of membranes
Mikko J Loukovaara1, Henrik V Alfthan, M Tapio Kurki
1Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, 00290, Helsinki, Finland. mikko.loukovaara@hus.fi
Objective:
Low-grade inflammation may raise serum C-reactive protein (CRP) concentrations. We studied whether serum CRP is altered in preterm premature rupture of membranes (PPROM), which is frequently associated with an asymptomatic intrauterine infection.
Study Design:
CRP was quantitated with highly sensitive immunofluorometric (IFMA) and immunoenzymometric (IEMA) assays in 32 women with PPROM at 30.7+/-0.4 gestational weeks (mean+/-standard error of the mean) and in 27 gestational age-matched healthy women. The results were compared to those obtained by the conventional immunoturbidimetric method.
Results:
Twenty-three PPROM patients had a normal CRP value (
Conclusion:
The increase in the highly sensitive CRP in PPROM patients with constantly normal immunoturbidimetric CRP may reflect the presence of a subclinical inflammation.
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