Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Defining neuropathic pain.

Misha-Miroslav Backonja1

  • 1Departments of Neurology, Anesthesiology, and Rehabilitation Medicine, University of Wisconsin Medical School, University of Wisconsin, Madison.

Anesthesia and Analgesia
|August 23, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epidural Steroids for Cervical and Lumbar Radicular Pain and Spinal Stenosis Systematic Review Summary: Report of the AAN Guidelines Subcommittee.

Neurology·2025
Same author

Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations.

Pain·2012
Same author

Assessment of neuropathic pain in primary care.

The American journal of medicine·2009
Same author

Quantitative sensory testing and mapping: a review of nonautomated quantitative methods for examination of the patient with neuropathic pain.

The Clinical journal of pain·2009
Same author

A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain.

Pain·2009
Same author

Voluntary facial displays of pain increase suffering in response to nociceptive stimulation.

The journal of pain·2008
Same journal

Incomplete Recovery of Diaphragmatic Mechanics at a Train-of-Four Ratio of 0.90 to <0.95 Assessed by Dynamic Digital Radiography: A Proof-of-Concept Case Series.

Anesthesia and analgesia·2026
Same journal

Patients' Perspectives and Experiences of Participating in Anesthesia Research: A Qualitative Study.

Anesthesia and analgesia·2026
Same journal

Impact of Epidural-Related Maternal Fever on Neonatal Outcomes: A Single-Center Retrospective Case-Control Study Excluding Confirmed Histological Chorioamnionitis.

Anesthesia and analgesia·2026
Same journal

Patient Beliefs and Experiences of Adhering to Medical Therapies for Cardiovascular Comorbidities, Before Noncardiac Elective Surgery in South Africa: A Mixed-Methods Study.

Anesthesia and analgesia·2026
Same journal

Beyond Administrative Indices: Allostatic Load and Autonomic Dyshomeostasis as Biological Mediators of Intraoperative Cardiac Arrest.

Anesthesia and analgesia·2026
Same journal

In Response.

Anesthesia and analgesia·2026
See all related articles

This study distinguishes neuropathic pain from inflammatory pain and hypersensitivity disorders. It defines neuropathic pain by its neurological origin and associated sensory, motor, and autonomic symptoms.

Area of Science:

  • Pain research
  • Neurology
  • Clinical diagnostics

Background:

  • Clinical pain diagnoses lack specificity, hindering research and practice.
  • Distinguishing between neuropathic and inflammatory pain mechanisms is crucial.
  • Existing classifications of neuropathic pain require refinement.

Purpose of the Study:

  • To propose a clearer distinction between neuropathic and inflammatory pain.
  • To redefine neuropathic pain based on neurological dysfunction.
  • To characterize the diverse manifestations of neuropathic pain.

Main Methods:

  • Review of existing literature on pain mechanisms.
  • Analysis of clinical diagnostic criteria for pain disorders.
  • Proposed reclassification of neuropathic pain syndromes.

Related Experiment Videos

Main Results:

  • Neuropathic pain is defined as pain arising from neurological disease or injury.
  • Identified positive sensory phenomena (pain, dysesthesia, hyperalgesia).
  • Recognized negative sensory phenomena and motor/autonomic symptoms.

Conclusions:

  • A more specific definition of neuropathic pain improves clinical practice and research.
  • Differentiating neuropathic pain from other pain types is essential for targeted treatment.
  • Neuropathic pain presents with a complex array of sensory, motor, and autonomic disturbances.