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Nicotinamide ribosyl uptake mutants in Haemophilus influenzae
Mark Herbert1, Elizabeta Sauer, Graeme Smethurst
1Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom. mherbert@molbiol.ox.ac.uk
Infection and Immunity
|August 23, 2003
Abstract:
The gene for the nicotinamide riboside (NR) transporter (pnuC) was identified in Haemophilus influenzae. A pnuC mutant had only residual NR uptake and could survive in vitro with high concentrations of NR, but could not survive in vivo. PnuC may represent a target for the development of inhibitors for preventing H. influenzae disease.