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Stability of retrieved memory: inverse correlation with trace dominance
Mark Eisenberg1, Tali Kobilo, Diego E Berman
1Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
Science (New York, N.Y.)
|August 23, 2003
Summary
Memory reconsolidation, where retrieved memories may become unstable, is influenced by how strongly a memory controls behavior. This finding explains conflicting results in memory reconsolidation research.
Area of Science:
- Neuroscience
- Behavioral Neuroscience
- Memory Research
Background:
- Memory consolidation stabilizes memory traces, making them resistant to amnesia.
- The traditional view posits a single, one-time consolidation event per memory.
- Emerging evidence suggests retrieved memories may undergo reconsolidation, but findings are conflicting.
Purpose of the Study:
- To investigate the factors influencing memory reconsolidation.
- To reconcile conflicting findings regarding the reconsolidation of retrieved memories.
- To explore the relationship between memory stability and behavioral control.
Main Methods:
- Conditioned taste aversion in rats.
- Fear conditioning in medaka fish.
- Assessing memory stability and behavioral control after memory retrieval.
Main Results:
- Memory stability after retrieval is inversely correlated with the degree of behavioral control exerted by that memory.
- This inverse correlation was observed in both conditioned taste aversion and fear conditioning paradigms.
- The findings suggest a dynamic interplay between memory strength and its influence on behavior.
Conclusions:
- The degree of behavioral control by a retrieved memory influences its subsequent stability.
- This relationship may explain discrepancies in previous reconsolidation studies.
- Memory reconsolidation is not a uniform process but is modulated by the memory's current functional impact.
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