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Hypogonadism and diabetes.

M Betancourt-Albrecht1, G R Cunningham

  • 1Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.

International Journal of Impotence Research
|August 23, 2003
PubMed
Summary

Low testosterone is common in type II diabetes, influenced by age, obesity, and sex hormone-binding globulin (SHBG). Reduced SHBG may explain lower testosterone, but free testosterone deficiency is also prevalent.

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Area of Science:

  • Endocrinology
  • Metabolic Disorders

Background:

  • Type II diabetes is increasingly associated with low testosterone levels.
  • Factors like aging, obesity, and sex hormone-binding globulin (SHBG) influence this relationship.

Purpose of the Study:

  • To explore the association between type II diabetes and testosterone levels.
  • To investigate the role of SHBG and other factors in testosterone deficiency in diabetic patients.

Main Methods:

  • Review of existing clinical observations and studies.
  • Analysis of the impact of age, obesity, and SHBG on testosterone levels in type II diabetes.

Main Results:

  • Lower SHBG levels are observed in type II diabetes, potentially explaining overall testosterone reduction.
  • Free testosterone levels decline with age and obesity, leading to deficiency in many diabetic patients.
  • Conflicting evidence exists regarding the benefits of testosterone replacement therapy on insulin sensitivity.

Conclusions:

  • The relationship between type II diabetes and low testosterone is multifactorial, involving SHBG, age, and obesity.
  • Free testosterone deficiency is a significant concern in type II diabetes.
  • Further research is needed to clarify the role and efficacy of testosterone replacement therapy.

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