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[Prostatic neuroendocrine cells].
Mónica Herrero1, Adelaida Rodríguez, Hugo Cejas
13a Cátedra de Patología-Facultad de Ciencias Médicas-Hospital Misericordia Universidad Nacional de Córdoba.
Revista De La Facultad De Ciencias Medicas (Cordoba, Argentina)
|August 26, 2003
Summary
Neuroendocrine (NE) cells in the prostate, present in normal glands, hyperplasia, and adenocarcinoma, were morphologically identified using silver staining. These cells play a role in glandular regulation and may impact prostate cancer prognosis.
Area of Science:
- Urology
- Cell Biology
- Histopathology
Context:
- Prostatic neuroendocrine (NE) cells, part of a widespread system, regulate glandular epithelium in normal and hyperplastic prostates.
- These cells are found in prostatic adenocarcinoma and small cell carcinoma, with recent suggestions linking them to prostate cancer prognosis, especially in hormone-refractory cases.
Purpose:
- To morphologically identify neuroendocrine cells in normal prostate tissue, nodular hyperplasia, and adenocarcinoma using silver impregnation techniques.
Summary:
- Neuroendocrine cells were observed in normal glands and nodular hyperplasia, located between epithelial cells and basement membrane, or in the stroma.
- These cells contain argyrophil and argentaffin granules and exhibit cytoplasmic processes.
- In the single high-grade adenocarcinoma studied, neuroendocrine cells were increased in number, polymorphic, and isolated.
Impact:
- This study provides morphological insights into prostatic neuroendocrine cells across different conditions.
- Understanding the presence and morphology of these cells may contribute to better prostate cancer prognostication.