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[Granulosa cell tumors: structural and ultrastructural analysis].

G Martellotto1, S Frede, S Ortiz

  • 1I Cátedra de Patologia, Fac. de Ciencias Médicas, Hospital Nacional de Clínicas, Universidad Nacional de Córdoba. gmartellotto@hotmail.com

Revista De La Facultad De Ciencias Medicas (Cordoba, Argentina)
|August 26, 2003
PubMed
Summary

This study examined rare ovarian stromal tumors in two women, identifying nuclear atypia and Call Exner Bodies. These neoplasms present unpredictable behavior and hormonal production, impacting the genital apparatus.

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Area of Science:

  • Gynecologic pathology
  • Tumor ultrastructure
  • Ovarian neoplasms

Context:

  • Ovarian stromal tumors represent 5-12% of all ovarian tumors.
  • These neoplasms originate from the ovarian stromal component.
  • Understanding their characteristics is crucial for diagnosis and management.

Purpose:

  • To investigate the histopathological and ultrastructural features of ovarian stromal tumors.
  • To identify pathognomonic elements, specifically Call Exner Bodies.
  • To analyze the cellular morphology and surrounding tissue interactions.

Summary:

  • Histopathological analysis revealed nuclear atypia, indented nuclei, and prominent nucleoli in both cases.
  • Call Exner Bodies were observed in one case, characterized ultrastructurally by whirled fibrils and amorphous material.

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  • Infiltration of plasma cells around tumor cells was noted, alongside hormonal production implications.

    • Impact:

    • Highlights the diagnostic significance of Call Exner Bodies in ovarian stromal tumors.
    • Underscores the unpredictable behavior and potential hormonal effects of these rare neoplasms.
    • Provides insights into the ultrastructural characteristics for improved understanding and classification.