[Lipid peroxidation in the pathogenesis of primary open-angle glaucoma]
Related Experiment Video
Updated: Sep 20, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
Abstract:
19 tissue samplings of the iris and trabecula from 17 patients, aged 49 to 79, with primary open-angle glaucoma (POAG) of different stages were examined for the purpose of studying the condition of lipid membranes in the iridial and trabecular tissues by electron microscopy. The results are indicative of that the key role, in the POAG pathogenesis, belongs to lipid peroxidation of posterior and anterior leaves of the retinal pigment epithelium, which is an activator of apoptotic processes in the trabecular endothelium. Therefore, it is advisable to use the lipid- and water-soluble antioxidative drugs to correct the physiological antioxidative deficiency within a complex POAG treatment.
Related Concept Videos
Glaucoma: Overview
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Diabetic Retinopathy
Coronary Artery Disease II: Pathophysiology
Peripheral Artery Disease I: Introduction
