Individualizing therapy in gastric cancer

Although its incidence in developed countries has declined, gastric cancer remains one of the most common human malignancies. In western countries a shift from distal to proximal tumors has been noted during the past 15 years. Today, surgery is no longer the only treatment modality of gastric cancer, with the help of modern and sophisticated staging procedures it becomes increasingly possible to individually tailor therapy. Operative morbidity and mortality has markedly decreased. The importance of surgical expertise for short- as well as long-term outcome is emphasized. The knowledge of adequate surgery together with the use of combined modalities opens the door to the amelioration of the still dismal prognosis for patients with gastric cancer. This paper reviews the modern approach to gastric cancer using an individualized treatment concept.