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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Relation of thoracic aorta calcification on computed tomography and coronary risk factors to obstructive coronary
Kazuo Watanabe1, Tadayuki Hiroki, Nobuhiko Koga
1Department of Internal Medicine/Cardiology, Fukuoka University, Chikushi Hospital, Fukuoka, Japan.
Insights
Thoracic aorta calcification (TAC) and coronary risk factors are linked to obstructive coronary artery disease (CAD). More calcified locations and risk factors significantly increase the likelihood of developing CAD.
Area of Science:
- Cardiology
- Radiology
- Preventive Medicine
Background:
- Obstructive coronary artery disease (CAD) poses a significant health risk.
- Thoracic aorta calcification (TAC) is a potential indicator of cardiovascular disease.
- The relationship between TAC, coronary risk factors, and obstructive CAD requires further investigation.
Purpose of the Study:
- To determine the correlation between thoracic aorta calcification (TAC) and obstructive coronary artery disease (CAD).
- To assess the combined impact of TAC and traditional coronary risk factors on the presence of obstructive CAD.
Main Methods:
- A cohort of 225 Japanese patients underwent thoracic computed tomography (CT) and coronary angiography.
- TAC was assessed in four distinct thoracic aorta locations.
- The presence and number of coronary risk factors were evaluated alongside TAC for correlation with obstructive CAD.
Main Results:
- Thoracic aorta calcification (TAC) was detected in 185 out of 225 patients.
- 141 patients had significant obstructive coronary artery disease (CAD).
- A strong correlation was observed between the number of thoracic calcified locations, coronary risk factors, and the likelihood of obstructive CAD (p < 0.0001).
Conclusions:
- Both the extent of thoracic aorta calcification (TAC) and the number of coronary risk factors are independently and collectively associated with obstructive coronary artery disease (CAD).
- Patients with no TAC and no risk factors showed no CAD, highlighting the predictive value of these factors.
- The findings suggest that TAC assessment may aid in identifying individuals at higher risk for obstructive CAD.
Abstract:
The aim of this study was to investigate whether thoracic aorta calcification (TAC) on computed tomography (CT) and coronary risk factors had any correlation with obstructive coronary artery disease (CAD) on angiography. A total of 225 consecutive Japanese patients underwent both thoracic conventional helical CT and coronary angiography. The thoracic aorta was divided into 4 locations according to the aortic anatomy (inner curve of the aortic arch, aortic arch but not on the inner curve, ascending aorta, and thoracic descending aorta). The classified TAC and coronary risk factors were evaluated for the presence or absence of obstructive CAD. TAC was detected in 185 patients; 141 of 225 patients had significant obstructive CAD. All of the 13 patients with no TAC and no coronary risk factors had no CAD. The obstructive CAD rate with 1 thoracic calcified location and with no, 1, or 2 coronary risk factors was 10%, 58%, and 90%, respectively, and each showed a significant difference (p < 0.0001). The combinations of TAC and coronary risk factors with obstructive CAD were 1 or 2 thoracic calcified locations with 3 coronary risk factors, and 3 thoracic calcified locations with more than 2 coronary risk factors. Increasing thoracic calcified locations and increasing coronary risk factors indicated a higher likelihood of CAD.
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