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Related Experiment Videos

Exogenous porcine viruses.

P S Paul1, P Halbur, B Janke

  • 1Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. ppaul2@unl.edu

Current Topics in Microbiology and Immunology
|August 26, 2003
PubMed
Summary
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Porcine organs offer transplant potential but carry risks from swine viruses. Enhanced diagnostics and understanding viral pathogenesis are crucial for safe xenotransplantation.

Area of Science:

  • Veterinary Virology
  • Xenotransplantation
  • Public Health

Background:

  • Porcine organs are a promising source for human transplants.
  • Swine viruses pose a potential public health risk (xenozoonoses) due to adaptation in humans.
  • Limited diagnostic tests exist for many swine viruses, increasing xenotransplantation risks.

Purpose of the Study:

  • To review the characteristics, pathogenesis, detection, and xenozoonoses risk of selected exogenous swine viruses.
  • To highlight viruses posing the greatest risk, including swine influenza virus, paramyxoviruses, arteriviruses, and circoviruses.
  • To emphasize the need for better diagnostic methods and understanding of viral potential for human infection.

Main Methods:

  • Review of existing literature on swine viruses and their zoonotic potential.

Related Experiment Videos

  • Analysis of viral characteristics, pathogenesis in swine, and detection methods.
  • Assessment of xenozoonoses risk associated with porcine virus transplantation.

    • Main Results:

    • Several porcine viruses can infect fetuses and new viruses have emerged.
    • Swine viruses like influenza, paramyxoviruses, arteriviruses, and circoviruses present significant xenozoonoses risks.
    • Current diagnostic capabilities for swine viruses are insufficient for safe xenotransplantation.

    Conclusions:

    • Vigilance, monitoring, and improved understanding of viral pathogenesis are essential to mitigate xenozoonoses risk.
    • Development of rapid and reliable diagnostic tests is critical for ensuring the safety of porcine-derived materials for xenotransplantation.
    • Further in vitro and in vivo assessment of swine viruses' potential to infect humans is required.