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Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone)
Kazutoshi Watanabe1, Yasuhiro Morinaka, Katsuhiko Iseki
1Research and Development Division, Mitsubishi Pharma Corporation, Yokohama, Japan. Watanabe.Kazutoshi@mb.m-pharma.co.jp
Redox Report : Communications in Free Radical Research
|August 26, 2003
Abstract:
This paper describes the discovery of a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone, 1), as a potent antioxidant agent against lipid peroxidation. The structure-activity relationship of edaravone indicated that lipophilic substituents were essential to show its lipid peroxidation-inhibitory activity. In vivo studies revealed that edaravone showed brain-protective activity in a transient ischemia model.