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Effects of hormone replacement therapy on platelet activation in postmenopausal women
Jian Gu1, Dongzi Yang, Liang'an Wang
1Department of Obstetrics and Gynecology, Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China. doctorguj@yahoo.com.cn
Objective:
To assess the effects of hormone replacement therapy (HRT) on platelet activation in postmenopausal women compared with premenopausal women.
Methods:
The expressions of CD41 and CD62P in fifteen postmenopausal women before and after HRT were detected using flow cytometry (FCM), with fifteen premenopausal women with a mean age of 47 years as controls.
Results:
The expressions of CD41 and CD62P in postmenopausal women were higher than those in the control group. CD62P(%), CD62P(I) and CD41 were reduced from 36.40 +/- 5.9, 37.75 +/- 5.8, and 470.11 +/- 74.0 to 27.97 +/- 5.6, 26.64 +/- 4.9, and 303.23 +/- 72.8 after six months of HRT (P < 0.05).
Conclusions:
Platelet activation in postmenopausal women was higher than in premenopausal women and was reduced significantly after six months of HRT. HRT may have a favorable effect on reduction of platelet activity.