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Apolipoprotein E genotype in patients with Alzheimer's disease
Benyan Luo1, Zhi Chen, Yanyan Zhang
1Department of Neurology, First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310003, China. lobenyan@263.net
Chinese Medical Journal
|August 26, 2003
Abstract
Objective:
To explore the frequency and significance of ApoE gene polymorphisms in patients with sporadic Alzheimer's disease (AD).
Methods:
Single nucleotide polymorphisms of the ApoE gene were analyzed in 32 cases of AD and 26 controls, using PCR and gene sequencing.
Results:
The single nucleotide polymorphism of ApoE gene 462C/G was significantly associated with AD (P < 0.05).
Conclusions:
The 462C/G polymorphism might be a specific genotype in Chinese patients with sporadic AD.