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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Typing of Y chromosome single nucleotide polymorphisms in a Japanese population by a multiplexed single nucleotide
Sachiyo Inagaki1, Yuji Yamamoto, Yusuke Doi
1Department of Legal Medicine, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikatacho Okayama city, Japan. inagaki@md.okayama-u.ac.jp
Abstract:
We have developed a new method for typing single nucleotide polymorphisms (SNPs) on the human Y chromosome based on a multiplexed single nucleotide primer extension. This method has the advantage that several SNPs are typed rapidly and simultaneously. We examined 15 different SNP loci on Y chromosome, M9, M105, M122, M125, M128, M130, SRY465, IMS-JST006241, IMS-JST006841, IMS-JST002611, IMS-JST003305, IMS-JST008425, IMS-JST021354, IMS-JST021355 and IMS-JST055457, in 159 Japanese males. From the typing results of these 15 loci, we found 13 haplotypes. Gene diversity for each locus ranged from 0.025 to 0.486 and the haplotype diversity was estimated to be 0.838. This method could be readily applied for personal identification and paternity testing.
