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Updated: Sep 20, 2026

Human In-Vivo Bioassay for the Tissue-Specific Measurement of Nociceptive and Inflammatory Mediators
Published on: December 1, 2008
Microdialysis in pain research
Carl-Olav Stiller1, Bradley K Taylor, Bengt Linderoth
1Division of Clinical Pharmacology, Department of Medicine, Karolinska Hospital, SE-17177, Stockholm, Sweden.
Abstract:
In vivo microdialysis has been used in preclinical pain research for more than a decade. This valuable tool allows correlations between nociceptive behavior and neurotransmitter release in pain-related CNS sites. However, several methodological issues must be considered to adequately interpret microdialysis data. Thus, the aim of this review is to describe key considerations, potential pitfalls, and important control experiments. We focus on animal experiments which evaluate the effects of noxious stimulation on CNS neurotransmitter release, particularly those that address clinically relevant problems in patients with long-lasting painful conditions.

