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[Liver scanning in diffuse liver disease (author's transl)].

P Aiginger, K Atefie, O Scherak

    Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
    |August 1, 1975
    PubMed
    Summary

    Technetium-99m sulphur colloid liver scans reveal distinct patterns in diffuse liver diseases. Chronic aggressive hepatitis shows increased spleen uptake, while cirrhosis affects the spleen, liver lobe, and bone marrow.

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    Area of Science:

    • Nuclear medicine
    • Hepatology
    • Radiology

    Background:

    • Diffuse liver diseases encompass a range of conditions affecting liver function.
    • Liver scintigraphy is a diagnostic tool used to assess liver morphology and function.
    • Differentiating between various types of diffuse liver disease can be challenging.

    Purpose of the Study:

    • To evaluate the utility of 99mTc-sulphur colloid scintigraphy in diagnosing diffuse liver diseases.
    • To identify specific scintigraphic patterns associated with different liver pathologies.
    • To compare scintigraphic findings in patients with liver disease to normal controls.

    Main Methods:

    • Liver scans were performed using 99mTc-sulphur colloid.
    • 169 patients with diffuse liver diseases and 48 normal controls were included.

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  • Scintigraphic patterns were analyzed for colloid distribution and uptake.

    • Main Results:

    • Minimal deviations from normal scintigraphy were observed in reactive hepatitis, acute hepatitis, chronic persistent hepatitis, fatty liver, and fibrosis.
    • Chronic aggressive hepatitis demonstrated significantly increased colloid uptake in the spleen with normal intrahepatic distribution.
    • Liver cirrhosis showed increased colloid uptake in the left lobe, spleen, and bone marrow.
    • Alcoholic hepatitis presented with either normal findings or cirrhosis-like changes.

    Conclusions:

    • 99mTc-sulphur colloid scintigraphy can aid in differentiating certain diffuse liver diseases.
    • Specific patterns of colloid distribution, particularly spleen and bone marrow uptake, are indicative of advanced liver disease like cirrhosis.
    • Spleen uptake is a key indicator in chronic aggressive hepatitis.