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New plasmid-borne antibiotic resistance gene cluster in Pasteurella multocida
Corinna Kehrenberg1, Nga Thi Thu Tham, Stefan Schwarz
1Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), 31535 Neustadt-Mariensee, Germany.
Antimicrobial Agents and Chemotherapy
|August 26, 2003
Abstract:
A new antibiotic resistance gene cluster comprising genes for sulfonamide (sul2), streptomycin (strA-strB), and tetracycline [tetR-tet(H)] resistance was detected on plasmid pVM111 from Pasteurella multocida. The tetR-tet(H) gene region was inserted between sul2 and strA, possibly by illegitimate recombination. Two potential recombination sites of 18 and 25 bp were identified.