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Neonatal lenticulostriate vasculopathy: further characterisation
I R Makhoul1, I Eisenstein, P Sujov
1Department of Neonatology, Rambam Medical Center and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. makhoul@rambam.health.gov.il
Archives of Disease in Childhood. Fetal and Neonatal Edition
|August 26, 2003
Summary
Lenticulostriate vasculopathy (LSV) in neonates is often linked to perinatal issues. This study found LSV neonates had more multiple births but otherwise showed no significant adverse findings compared to controls.
Area of Science:
- Neonatal neurology
- Pediatric neuroimaging
- Perinatal medicine
Background:
- Lenticulostriate vasculopathy (LSV) is identified via neonatal brain ultrasonography.
- LSV is often associated with perinatal and neonatal abnormalities.
- Previous LSV research is largely retrospective and lacks control groups.
Purpose of the Study:
- To compare perinatal and neonatal clinical characteristics of neonates with LSV against matched controls.
- To summarize published reports on LSV.
- To evaluate the clinical significance of LSV in newborns.
Main Methods:
- A prospective study analyzing clinical, laboratory, and neurosonographic data.
- 857 neonates underwent routine head ultrasound; 21 showed LSV.
- LSV cases were compared to 42 matched controls.
Main Results:
- LSV occurred in 2.45% of neonates studied.
- LSV was bilateral in 10 cases, predominantly in the thalamus and basal ganglia.
- LSV neonates had more multiple births and amniotic fluid disturbances but fewer adverse outcomes like blood transfusions or phototherapy.
Conclusions:
- Neonates with LSV showed no significant increase in adverse findings compared to controls, apart from a higher incidence of multiple births.
- LSV detection on neonatal ultrasound warrants careful consideration of perinatal factors.
- Further research may clarify the long-term implications of LSV.