Related Experiment Video

Updated: Aug 17, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Tyrosine kinase src inhibitors: potential therapeutic applications

M Susa1, A Teti

  • 1Department of Arthritis and Bone Metabolism, Unit Bone Metabolism, Research Bone Metabolism, Novartis Pharma AG, Basel, Switzerland.

Drug News & Perspectives
|August 26, 2003
PubMed

Insights

Tyrosine kinase Src plays a key role in bone resorption. New Src family kinase inhibitors show therapeutic potential for bone loss and bone metastases, offering a novel treatment strategy.

Area of Science:

  • Biochemistry
  • Oncology
  • Bone Biology

Background:

  • The tyrosine kinase Src is a proto-oncogene and a prototype for non-receptor tyrosine kinases.
  • Src has a critical role in osteoclast function and bone resorption.
  • Research into Src's specific substrates and functions is ongoing.

Purpose of the Study:

  • To review the cellular and molecular mechanisms of Src kinase inhibitors.
  • To explore the therapeutic potential of Src kinase inhibitors in bone diseases and cancer-induced bone metastases.

Main Methods:

  • Review of recent scientific literature on Src kinase inhibitors.
  • Analysis of cellular and animal models of bone loss.
  • Characterization of selective, potent, and orally available Src family kinase inhibitors.

Main Results:

  • Src family kinase inhibitors have been identified and characterized.
  • These inhibitors demonstrate potential in preclinical models of bone loss.
  • The mechanisms through which these inhibitors act are being elucidated.

Conclusions:

  • Src kinase inhibitors represent a novel therapeutic tool.
  • They hold promise for treating bone disorders and bone metastases from cancer.
  • Further research into their application is warranted.

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