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Updated: Aug 14, 2026

Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties
Published on: January 8, 2016
Polymer-directed enzyme prodrug therapy
1Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, UK.
Abstract:
Over the last 20 years many attempts have been made to develop a drug targeting or delivery system that could avoid the problems of organ toxicity and drug resistance. Polymer-directed enzyme prodrug therapy is an attempt to produce a targeting and delivery system that will improve the therapeutic index. Components of the system are polymers--used as the drug carrier, drugs and linkers. A number of polymer-directed enzyme prodrug therapies have been tested in the clinic; results obtained in a phase I trial with PK1 are described.
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