Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymer-directed enzyme prodrug therapy.

J Cassidy1

  • 1Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, UK.

Drug News & Perspectives
|August 26, 2003
PubMed
Summary

Polymer-directed enzyme prodrug therapy aims to improve drug delivery and reduce toxicity. Early clinical trials show promise for this targeted approach in cancer treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Properties of Heavy Cosmic Nuclei Phosphorus, Chlorine, Argon, Potassium, and Calcium: Results from the Alpha Magnetic Spectrometer.

Physical review letters·2026
Same author

Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2023
Same author

Barriers to older adults seeking sexual health advice and treatment: A scoping review.

International journal of nursing studies·2020
Same author

Improving the spectral resolution in fluorescence microscopy through shaped-excitation imaging.

Methods and applications in fluorescence·2018
Same author

Care in subsequent pregnancies following stillbirth: an international survey of parents.

BJOG : an international journal of obstetrics and gynaecology·2016
Same author

Fasciola hepatica infection reduces Mycobacterium bovis burden and mycobacterial uptake and suppresses the pro-inflammatory response.

Parasite immunology·2016

Area of Science:

  • Biomedical Engineering
  • Pharmacology
  • Oncology

Background:

  • Developing effective drug delivery systems is crucial to overcome challenges like organ toxicity and drug resistance.
  • Traditional therapies often struggle with a narrow therapeutic index, limiting efficacy and increasing side effects.

Purpose of the Study:

  • To evaluate polymer-directed enzyme prodrug therapy as a novel strategy for targeted drug delivery.
  • To assess the potential of this approach to improve the therapeutic index of anticancer agents.

Main Methods:

  • Utilizing polymers as drug carriers linked to specific drugs.
  • Employing enzyme-activated prodrugs for targeted release at the disease site.
  • Conducting clinical trials to assess safety and preliminary efficacy.

Main Results:

  • A phase I clinical trial was conducted to evaluate a specific polymer-directed enzyme prodrug therapy (PK1).
  • Initial results from the trial are presented, providing insights into the system's performance in patients.

Conclusions:

  • Polymer-directed enzyme prodrug therapy represents a promising strategy for enhancing drug targeting and delivery.
  • Further clinical investigation is warranted to fully establish the therapeutic benefits of this innovative approach.

Related Experiment Videos