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Published on: July 1, 2018
[Aseptic meningitis caused by the rupture of an epidermoid cyst]
A Pampliega-Pérez1, C Martín-Estefanía, M Caballé-Tura
1Servicio de Neurología, Hospital General Universitario de Alicante, Alicante, España. apampliega@yahoo.com
Introduction:
Epidermoid cysts are rare tumours. The aseptic meningitis that comes about as a result of their rupture is frequent after tumour resection, although they may occasionally occur spontaneously.
Case Report:
A 36-year-old male who had been submitted to surgery twice because of an epidermoid cyst in the cerebellopontine angle presented a month old history of clinical features consisting in high temperature, headache, a stiff neck and ataxia. After computerized tomography (CT) scans and a spinal tap had been performed because of the suspicion of meningitis, empirical antibiotic therapy was administered but no improvement was observed. Thus, the usual studies employed to diagnose aseptic meningitis were carried out. Magnetic resonance imaging (MRI) was performed and showed lesions that suggested tumorous recurrence and perilesional meningeal hyperenhancement. Corticoid therapy quickly lessened the symptoms and the patient was asymptomatic when discharged. A week later he returned with headaches and disorders affecting behaviour and memory. A CT scan was performed and revealed the presence of tetraventricular hydrocephalus, which required the introduction of ventriculoperitoneal drainage. Spinal MRI carried out two weeks later revealed perimedullar foci of hyperenhancement.
Conclusions:
We describe the case of a patient with aseptic meningitis brought on by the rupture of an epidermoid cyst, which followed a subacute course and responded to corticoid therapy in a spectacular manner. Nevertheless, the patient still went on to develop tetraventricular hydrocephalus. Spontaneous aseptic meningitis is rare and corticoids lower its development time, but hydrocephalus may occur as a complication due to upsets in the reabsorption of cerebrospinal fluid.
Insights
Ruptured epidermoid cysts can cause aseptic meningitis, a rare condition. Corticosteroid therapy can alleviate symptoms, but complications like hydrocephalus may still occur due to cerebrospinal fluid reabsorption issues.
Area of Science:
- Neurology
- Neurosurgery
- Pathology
Background:
- Epidermoid cysts are uncommon tumors, and their rupture can lead to aseptic meningitis, particularly post-operatively.
- Spontaneous aseptic meningitis secondary to epidermoid cyst rupture is a rare clinical presentation.
Observation:
- A 36-year-old male presented with symptoms suggestive of meningitis following two prior surgeries for a cerebellopontine angle epidermoid cyst.
- Initial antibiotic therapy was ineffective; subsequent MRI revealed suspected tumor recurrence and meningeal enhancement.
- Corticosteroid treatment provided temporary symptom relief, but the patient later developed tetraventricular hydrocephalus requiring surgical intervention.
Findings:
- The case highlights a subacute presentation of aseptic meningitis caused by a ruptured epidermoid cyst.
- Corticosteroid therapy demonstrated efficacy in managing the inflammatory meningitis symptoms.
- Tetraventricular hydrocephalus emerged as a significant complication, indicating disruption of cerebrospinal fluid dynamics.
Implications:
- This case underscores the importance of considering ruptured epidermoid cysts in the differential diagnosis of aseptic meningitis, even with a history of surgery.
- While corticosteroids can be beneficial for symptom management, potential complications such as hydrocephalus necessitate vigilant monitoring and appropriate neurosurgical management.
- Understanding the pathophysiology of cerebrospinal fluid reabsorption disturbances is crucial for managing such rare neurological complications.
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