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Related Experiment Videos

Speciation and inversions: chimps and humans.

Jody Hey1

  • 1Department of Genetics, Rutgers, the State University of New Jersey, 604 Allison Rd. Piscataway, NJ 08854-8082, USA. hey@biology.edu

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|August 26, 2003
PubMed
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New models suggest chromosomal inversions aid speciation by altering recombination rates. A study found high amino-acid substitution in human-chimp inversion regions, hinting at inversions

Area of Science:

  • Evolutionary biology
  • Genetics

Background:

  • Chromosomal inversions were previously thought to aid speciation by reducing hybrid fitness.
  • Recent models propose inversions influence speciation through effects on local recombination rates.

Purpose of the Study:

  • To investigate the role of chromosomal inversions in speciation.
  • To test newer models focusing on recombination rates and inversions.

Main Methods:

  • Analysis of genomic regions with chromosomal differences between humans and chimpanzees.
  • Examination of amino-acid substitution rates in these regions.

Main Results:

  • A high rate of amino-acid substitution was observed in regions differing by inversions between humans and chimpanzees.

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  • This finding suggests a potential role for inversions in the divergence of ancestral species.

    • Conclusions:

    • The study provides evidence that chromosomal inversions may play a significant role in the speciation process.
    • Further research is needed to confirm if the observed findings align with proposed models of inversion-driven speciation.