Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Intracoronary brachytherapy: a meta-analysis].

E Charpentier1, N Danchin, C Edlinger

  • 1Hôpitaux de Paris, 3, avenue Victoria, 75100 Paris, France. emmanuel.charpentier@sap.ap-hop-paris.fr

Annales De Cardiologie Et D'Angeiologie
|August 27, 2003
PubMed
Summary

Intracoronary brachytherapy shows angiographic benefits for reducing in-stent restenosis. However, a meta-analysis revealed increased adverse clinical effects, precluding its routine use.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Cardiac sarcoidosis: Diagnosis, prognosis and therapeutics].

La Revue de medecine interne·2022
Same author

[The aftermath of the COVID-19 pandemic an opportunity to reform health].

Bulletin de l'Academie nationale de medecine·2022
Same author

Candida bloodstream infection in patients with systemic autoimmune diseases.

Medecine et maladies infectieuses·2020
Same author

Specific antibacterial activity of copper alloy touch surfaces in five long-term care facilities for older adults.

The Journal of hospital infection·2019
Same author

A 2-year multicenter, observational, prospective, cohort study on extracorporeal CO<sub>2</sub> removal in a large metropolis area.

Journal of intensive care·2019
Same author

Performance evaluation of different strategies based on microscopy techniques, rapid diagnostic test and molecular loop-mediated isothermal amplification assay for the diagnosis of imported malaria.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Radiation Oncology

Background:

  • In-stent restenosis is a significant complication after coronary interventions.
  • Intracoronary brachytherapy has been explored to reduce neointimal hyperplasia and restenosis.
  • The clinical efficacy and safety require comprehensive evaluation.

Purpose of the Study:

  • To systematically review and meta-analyze the clinical outcomes of intracoronary brachytherapy for in-stent restenosis.
  • To assess the angiographic and clinical benefits versus risks of this therapeutic approach.

Main Methods:

  • A systematic review of prospective randomized clinical trials was conducted.
  • Seven trials comparing intracoronary brachytherapy with control groups were included in the meta-analysis.

Related Experiment Videos

  • Angiographic and clinical adverse event data were analyzed.

    • Main Results:

    • The meta-analysis confirmed the angiographic benefit of intracoronary brachytherapy in reducing in-stent restenosis.
    • An excess of clinical adverse effects was observed, which was not apparent in individual studies.
    • No single trial demonstrated a statistically significant increase in adverse events.

    Conclusions:

    • Intracoronary brachytherapy demonstrates angiographic efficacy but is associated with increased clinical adverse events.
    • The procedure cannot be recommended for routine clinical practice.
    • Potential benefits in specific patient subsets warrant further investigation.