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Published on: July 10, 2012
Reversible cortical blindness after lung transplantation.
Mark T Knower1, Scott D Pethke, Vincent G Valentine
1Department of Multi-Organ Transplant, Ochsner Clinic Foundation, New Orleans, LA, USA.
Southern Medical Journal
|August 27, 2003
Summary
Cyclosporine (CYA) can cause rare, reversible cortical blindness after organ transplants. Early diagnosis and dose adjustment of this immunosuppressant can restore vision.
Area of Science:
- Nephrology
- Neurology
- Transplantation Medicine
Background:
- Cyclosporine (CYA), a calcineurin inhibitor, is crucial for immunosuppression post-transplantation.
- Neurologic side effects are known, but reversible cortical blindness is a rare complication.
Observation:
- This report details a case of reversible cortical blindness following lung transplantation.
- It also reviews 28 prior documented cases of CYA-induced cortical blindness after various transplants.
Findings:
- Risk factors, clinical signs, and radiographic indicators for CYA-induced cortical blindness were identified.
- The condition is typically associated with liver and bone marrow transplants but is now reported after lung transplantation.
Implications:
- Recognizing risk factors and clinical clues aids in diagnosing CYA toxicity.
- Reducing CYA dosage or discontinuing therapy often leads to visual recovery.
