Radioprotection effect of low level preirradiation on mammals: modeling and experimental investigations

This paper is devoted to experimental and theoretical studies of low level preirradiation effects on radiosensitivity of mammals. It is shown experimentally that a priming exposure to a low dose can induce radioresistance in mice in two (early and late) periods after preirradiation. The manifestation of such effects is reduced mortality of preexposed specimens after challenge acute irradiation, the reason of the animal death being the hematopoietic subsyndrome of the acute radiation syndrome. Therefore, proceeding from the radiobiological concept of critical system, the theoretical investigation of the influence of preirradiation on mammalian radiosensitivity is conducted by making use of the mathematical models of the vital body system, hematopoiesis. Modeling results obtained make it possible to elucidate the mechanisms of the radioprotection effect of low level priming irradiation on mammals. Specifically, the state of acquired radioresistance in mice is caused by reduced radiosensitivity of lymphopoietic and thrombocytopoietic systems in the early period and by reduced radiosensitivity of granulocytopoietic system, which is accompanied by slightly reduced or close to the normal level radiosensitivity of lymphopoietic system, in the late period after preirradiation. In turn, reduced radiosensitivity of above-noted hematopoietic lines is the consequence of hypercompensation of radiation damages of certain cell pools during the recovering processes running in these systems after priming irradiation. It is important to emphasize that the evaluations of the duration of the early and late periods of postirradiation radioresistance in mice, carried out on the basis of the modeling and experimental investigations, practically coincide. All this demonstrates the effectiveness of joint modeling and experimental investigations of such complicated radiobiological problems as acquired radioresistance.