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Bone morphogenetic protein-4 gene polymorphism and early marginal bone loss around endosseous implants
Hitomi Shimpuku1, Yasuhiro Nosaka, Tatsuya Kawamura
1Department of Pharmacology, Osaka Dental University, Hirakata, Osaka, Japan. nskshimpuku@aol.com
The International Journal of Oral & Maxillofacial Implants
|August 27, 2003
Summary
The bone morphogenetic protein-4 (BMP-4) genetic polymorphism is linked to early marginal bone loss around dental implants. Genetic screening may help assess implant treatment risks.
Area of Science:
- Genetics
- Oral Surgery
- Biomaterials
Background:
- Early marginal bone loss around dental implants is a clinical concern with unclear etiology.
- Bone morphogenetic protein-4 (BMP-4) plays a role in bone metabolism and regeneration.
Purpose of the Study:
- To investigate the association between BMP-4 genetic polymorphism and early marginal bone loss around dental implants.
- To determine if specific BMP-4 genotypes increase the risk of bone loss post-implantation.
Main Methods:
- BMP-4 polymorphism was analyzed using polymerase chain reaction and HphI digestion.
- 262 implants in 41 patients were assessed for early marginal bone loss.
- Restriction fragment length analysis was employed to detect BMP-4 genotypes.
Main Results:
- A significantly higher incidence of marginal bone loss was observed in the mandible for patients with the BMP-4 AV genotype compared to the W genotype (P = .012).
- Multiple logistic regression indicated an odds ratio of 8.106 for bone loss in the mandible associated with the BMP-4 AV genotype versus the W genotype (95% CI = 1.30 to 50.51; P = .025).
Conclusions:
- The BMP-4 genetic polymorphism appears to influence the occurrence of early marginal bone loss around dental implants.
- Pre-implant genetic screening for BMP-4 variants could potentially aid in risk assessment for dental implant treatment.