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Related Experiment Videos

Arterial transit time imaging with flow encoding arterial spin tagging (FEAST).

Jiongjiong Wang1, David C Alsop, Hee Kwon Song

  • 1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. jwang@rad.upenn.edu

Magnetic Resonance in Medicine
|August 27, 2003
PubMed
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Flow encoding arterial spin tagging (FEAST) offers a novel method for measuring arterial transit time, reducing motion and computational errors common in other techniques. This technique provides accurate cerebral blood flow insights, particularly useful in cerebrovascular disease assessment.

Area of Science:

  • Neuroimaging
  • Medical Physics
  • Cardiovascular Imaging

Background:

  • Arterial spin labeling (ASL) is a key MRI technique for quantifying cerebral blood flow (CBF).
  • Assessing arterial transit time (ATT) is crucial for understanding brain perfusion dynamics.
  • Current ATT methods using ASL often require multiple scans, increasing susceptibility to artifacts and errors.

Purpose of the Study:

  • To introduce and validate the flow encoding arterial spin tagging (FEAST) technique for measuring tissue transit time.
  • To provide a theoretical basis and experimental evidence for the FEAST method.
  • To assess the utility of FEAST in patients with cerebrovascular disease.

Main Methods:

  • Development of the FEAST technique utilizing bipolar gradients to measure tissue transit time.

Related Experiment Videos

  • Derivation of transit time from the ratio of ASL signals with and without bipolar gradients.
  • Experimental validation using steady-state imaging and application in patients with cerebrovascular disease.

    • Main Results:

    • FEAST allows for transit time measurement from a single ASL acquisition, mitigating motion and computational issues.
    • Global mean tissue transit times were measured at approximately 1100 ms and 1400 ms under different encoding velocities.
    • Shorter transit times were observed in the deep middle cerebral artery (MCA) territory.
    • FEAST demonstrated prolonged transit times in affected areas of patients with cerebrovascular disease, correlating with other MRI findings.

    Conclusions:

    • FEAST is a promising technique for accurate and robust measurement of tissue transit time.
    • This method enhances the diagnostic capabilities of ASL in evaluating cerebrovascular conditions.
    • FEAST offers a valuable alternative to existing multi-timepoint ASL methods for ATT assessment.