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Published on: March 8, 2019
[Alpha-1 antitrypsin concentration and atherosclerosis risk factors in patients with abdominal aortic aneurysm]
Maria Knapik-Kordecka1, Romana Doskocz, Rajmund Adamiec
1Katedra i Klinika Angiologii, Nadciśnienia Tetniczego i Diabetologii Akademii Medycznej we Wrocławiu.
Abstract:
The aim of the study was an assessment of alpha 1-antitrypsin (alpha 1-AT) serum concentration in patients with abdominal aortic aneurysm and investigation the relationship between alpha 1-AT and parametric and non-parametric atherosclerosis risk factors. A statistically significant increase of alpha 1-AT concentration was demonstrated in the group of patients as compared to healthy subjects; the alpha 1-AT concentration demonstrated no correlation with aneurysm diameter. A positive correlation was found between alpha 1-AT level and the age of the studied patients; the alpha 1-AT concentration demonstrated no correlation with the remaining risk factors of atherosclerosis. alpha 1-AT may be regarded as a marker of inflammatory lesions in abdominal aortic aneurysms, directly independent of atherosclerosis risk factors.
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