Related Experiment Videos
[Isotype switching of produced immunoglobulins in multiple myeloma]
Arkadiusz Drobiecki1, Elzbieta Kisiel, Ewa Wasińska
1Dział Onkohematologii Swietokrzyskiego Centrum Onkologii w Kielcach, 25-734 Kielce, ul. Artwińskiego 3.
Przeglad Lekarski
|August 28, 2003
Abstract:
Multiple myeloma is usually characterized by production of a single serum monoclonal protein of constant isotype and light chain restriction. Isotype switching in human lymphomas appears to be an uncommon event. It could be due to altered para-protein production by the malignant plasma cell clone, or oligoclonal Ig production during recovery of B-cell function after chemotherapy. We describe a case of clonal heavy chain isotype switching in a patient with lymphoplasmocytic lymphoma.