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Updated: Aug 17, 2026
Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
Published on: May 9, 2013
[Evaluation of cerebral circulatory compensation after carotid artery occlusion in rabbits]
1Department of Neurosurgery, PLA General Hospital, Beijing 100853, China. zhoutaolayn@fm365.com
Objective:
To observe the cerebral circular changes of rabbits during brain ischemia caused by carotid artery occlusion (CAO) with a loading test-cerebral vascular CO2 reactivity (CVR) technique.
Methods:
Sixty white rabbits were divided into 6 groups, before and during 0-50 days after CAO, we studied the regional cerebral blood flow (rCBF) and CVR of frontal lobe on the same side, using laser doppler perfusion imager (LDI).
Result:
The rCBF-lesion caused by CAO could hardly be observed (P > 0.5), but CVR cut down obviously (P < 0.01).
Conclusions:
The loading test-cerebral vascular CO2 reactivity (CVR) allow the hemodynamic effect of a CAO on the intracerebral circulation to be observed before the reduced rCBF can be detected.
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