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Published on: June 25, 2017
[Expression of glucose transporter-1 in endometrial hyperplasia and well-differentiated endometrioid adenocarcinoma]
1Department of Pathology, PLA General Hospital, Beijing 100853, China. chenlezh@public.bta.net.cn
Objective:
To investigate the expression of glucose transporter-1 (GLUT1) in endometrial hyperplasia and well-differentiated endometrioid adenocarcinomas.
Methods:
Sixty formalin fixed, paraffin-embedded sections of various endometrial hyperplasia and well-differentiated endometrioid adenocarcinomas were immunostained with rabbit anti-GLUT1 antibody using streptavidin-biotin method.
Results:
Two of 12 simple hyperplasia and one of seven complex hyperplasia without atypia were focally positive in metaplastic epithelia. All complex atypical hyperplasia showed positive in varied degree, and 26 among 28 cases of adenocarcinoma were stained positively.
Conclusions:
Overexpression of GLUT1 is a consistent feature of atypical hyperplasia and adenocarcinoma. GLUT1 immunostaining is found to be helpful in distinguishing hyperplasia with atypia from those without atypia.
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Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Hyperglycemia
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