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Exercise and cardiac oxidative stress.

António Ascensão1, José Magalhães, José Soares

  • 1Faculdade de Ciências do Desporto e de Educação Física-Universidade do Porto, Porto. aascensao@fcdef.up.pt

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|August 28, 2003
PubMed
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Physical exercise increases reactive oxygen species in cardiac muscle. However, endurance training enhances antioxidant defenses, offering protection against exercise-induced oxidative stress, though underlying mechanisms require further study.

Area of Science:

  • Cardiovascular Physiology
  • Oxidative Stress Biology

Background:

  • Cardiac muscle is susceptible to oxidative stress from stimuli like physical exercise.
  • Exercise increases reactive oxygen species (ROS) production, potentially impacting cardiac health.
  • The heart's high metabolic rate and limited antioxidant capacity heighten vulnerability to exercise-induced oxidative injury.

Purpose of the Study:

  • To investigate the impact of physical training on cardiac antioxidant systems.
  • To explore how endurance training influences myocardial protection against oxidative stress.

Main Methods:

  • Analysis of antioxidant enzyme activity (superoxide dismutase, glutathione peroxidase) and glutathione levels in cardiac muscle.
  • Evaluation of changes in antioxidant defenses following endurance training protocols.

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Main Results:

  • Physical training, particularly endurance training, stimulates antioxidant systems in cardiac muscle.
  • Up-regulation of glutathione and key antioxidant enzymes (superoxide dismutase, glutathione peroxidase) was observed.
  • These adaptations suggest enhanced myocardial protection against oxidative stress.

Conclusions:

  • Endurance training confers a protective effect on cardiac muscle against oxidative stress.
  • The cross-tolerance effect of training on cardiac antioxidant defenses warrants further investigation into its mechanisms.