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Hyperthyroidism in two patients with Crohn disease and Takayasu arteritis
A Kettaneh1, S Prevot, A Biaggi
1Dept. of Internal Medicine, Hôpital Jean Verdier, Bondy, France. adrien.kettaneh@jvr.ap-hop-paris.fr
Scandinavian Journal of Gastroenterology
|August 28, 2003
Summary
This study reports two cases of hyperthyroidism in patients with Crohn disease and Takayasu arteritis. The findings suggest a potential link between these conditions, possibly due to genetic factors and iodine deficiency impacting the Nuclear Factor kappaB pathway.
Area of Science:
- Endocrinology
- Gastroenterology
- Rheumatology
Background:
- Crohn disease (CD), Takayasu arteritis (TA), and thyroid abnormalities are independently observed in patients.
- This report details two cases of concurrent hyperthyroidism, CD, and TA.
Observation:
- Two women presented with hyperthyroidism alongside pre-existing CD and TA.
- Diagnostic evaluations included thyroid function tests, antibody assays, ultrasonography, and iodine uptake scans.
- Both patients underwent subtotal thyroidectomy due to persistent thyrotoxicosis.
Findings:
- Neither patient had detectable anti-thyrotropin receptor (TRAK) or anti-thyroid antibodies.
- Thyroid imaging revealed multinodular goiter and hot nodules in both cases.
- The co-occurrence of these three conditions suggests a potential non-fortuitous association.
Implications:
- The shared association may stem from genetic predispositions and disease-related iodine deficiency.
- The Nuclear Factor kappaB pathway is hypothesized to play a role in the pathogenesis of this triad of diseases.
- Further research is warranted to elucidate the underlying mechanisms connecting CD, TA, and thyroid dysfunction.